AlphaVax, Inc. (AVX, Research Triangle Park, NC), a privately-held, clinical-stage biopharmaceutical company, has used its proprietary alphavaccine vector platform technology to generate a portfolio of vaccine candidates for infectious disease prevention and cancer immunotherapy. Three alphavccine candidates, targeting human cytomegalovirus, influenza A virus or HIV-1, have been evaluated in four Phase 1 clinical trials. More recently, AVX has focused efforts on the development of immunotherapeutic vaccines for the treatment of various cancers.

From these recent efforts, AVX has successfully progressed the development of its proprietary alphavaccine technology, to create new, potentially first-in-class vaccines that engage the patient’s immune system to both recognize and fight off various cancers. Results from AVX’s first trial evaluating its CEA alphavaccine in patients with Stage IV colon cancer, showed the vector technology was able to “break self-tolerance” and a trend for enhanced survival in patients with CEA-specific T cell responses. To follow up, AVX will initiate and complete clinical trials in breast cancer, colon cancer (in Stage III patients) and melanoma over the next three years.

• Successfully completed the manufacture, testing and release of AVX901, a HER2-VRP vaccine for a Phase I study in advanced and metastatic breast cancer in which patient enrollment began in 3Q 2012 at the Duke University Medical Center.
• Executed an exclusive license with the US Department of Defense (DoD), Office of Chemical-Biological Medical Systems (CBMS) to the alphavaccine platform for the development of Marburg and Ebola vaccines. This license enables the DoD to develop these vaccines in return for payments related to licensing and technology transfer.
• In April 2011, the Board of Directors of the Company was expanded to six directors. The new members bring significant experience in managing and growing pharmaceutical and biotechnology companies.
• In January 2012, an amended agreement with Novartis Vaccines and Diagnostics was executed in which certain obligations of both companies were re-defined. AVX also received payments related to technology transfer.
• Relocated manufacturing operations to its headquarters in Research Triangle Park, NC, thereby improving efficiency and reducing expense.